The aim of this study is to examine the predictors of five factor personality traits and resilience levels on compassion fatigue and sub-dimension scores among healthcare workers. In the study, in which the relational model was used, 697 health workers from different professions, especially nurses, physicians and midwives, took part. Personal Information Form, Compassion Fatigue-Short Scale, Adjective Based Personality Test and Brief Psychological Resilience Scale were used as data collection tools. The data were analyzed with the SPSS 25.0 statistical program. Pearson Moments Product Correlation Coefficient, Hierarchical Multiple Regression Analysis, independent groups t-test, One-way analysis of variance (ANOVA) and Mann-Whitney U Test were used to answer the problems put forward in the study. According to the beta coefficient (β) neuroticism, resilience, and work related to COVID-19 variables explain 26,2 % of the total variance of compassion fatigue, respectively. It was found that compassion fatigue and sub-dimension scores differ according to working with COVID-19, perceived increase in workload and anxiety about being contagious. The findings were discussed on the basis of the literature and in the last part, suggestions were presented within the framework of the results.World.